MORPHINE SULFATE ER (KADIAN) Do not stop taking KADIAN® or any other opioid without talking to your healthcare professional. KADIAN® can cause physical dependence. This means you could become sick with uncomfortable withdrawal symptoms because your body has become used to these medicines. Physical dependence is not the same as drug addiction. Your doctor can tell you more about the differences between physical dependence and drug addiction. • KADIAN® capsules are an extended-release capsule taken by mouth of morphine sulfate that is used to manage moderate to severe pain that continues around-the-clock and is expected to last for an extended period of time. • KADIAN® is NOT for use to treat pain that occurs once in a while (as needed). • KADIAN® is not indicated for pain in the immediate post-operative period (12-24 hours following surgery) for patients who have not taken drugs called opioids before. • KADIAN® is not indicated for pain in the post-operative period if the pain is mild or not expected to persist for an extended period of time. BEFORE USING THIS MEDICINE: Tell your doctor if you are having any of the following conditions: TOP CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD); ASTHMA; LIVER PROBLEMS; KIDNEY DISEASE. * Inform your Doctor or Pharmacist if you are allergic to any prescription or non-prescription medicine; taking other medicines or have other medical problems; pregnant, planning a pregnancy, or breastfeeding. * Check with your Doctor, Pharmacists, or Nurse if information in this leaflet causes you special concern or if you want additional information about your medicine and its use. HOW MEDICINE IS ADMINISTERED? TOP Use this medicine exactly as directed on the label, unless instructed differently by your doctor * This medicine can be taken with or without food, REGARDLESS of meal times. If stomach upset occurs, take with food. * Do not DISCONTINUE this medicine ABRUPTLY after prolonged usage. * Do not CRUSH or CHEW controlled-release product. WARNINGS/PRECAUTIONS: TOP * Safety of use during pregnancy has not been established. This medicine SHOULD NOT BE USED DURING PREGNANCY unless benefit justifies potential risk to the fetus. CALL YOUR DOCTOR. * This medicine may cause drowsiness, dizziness, or blurred vision. DO NOT drive or operate machines until you know how you react to this medicine. * AVOID concurrent use of alcohol or other CNS depressants as it may intensify the drowsiness, dizziness, or lightheadedness effect of this medicine. * This medicine may cause dizziness, lightheadedness or fainting. Avoid sudden changes in posture. BE CAREFUL and slowly sit up or stand up. * Prolonged use of this medication may cause physical and psychological dependence, do not exceed recommended dose. Stop taking this medicine and notify your doctor AS SOON AS POSSIBLE if you experience: Shortness of breath; Irregular heartbeat; Low blood pressure; Hot sensation and redness of face. Other Common Side Effects: TOP Constipation; Nausea; Sedation; Dizziness; Vomiting; Dry mouth; Sweating; Respiratory depression; Drowsiness; Slowness of heartbeat; Cns depression. Other Common Side Effects: If symptoms are mild but do not go away or are bothersome, check with your doctor. IF ANY OF THE ABOVE SIDE EFFECTS IS SEVERE, CALL YOUR DOCTOR IMMEDIATELY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. This leaflet has been developed by CliniDATA Source, Inc. based primarily on labeling information provided by the manufacturer. The information does not cover all possible uses, actions, precautions, side effects, or interactions of this medicine. It is not intended as medical advice for individual patients. Copyright © CliniDATA Source, Inc. 03/14. All rights reserved