PACLITAXEL PROTEIN-BOUND INJ. (ABRAXANE) ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. ABRAXANE therapy should not be administered to patients with metastatic breast cancer who have baseline neutrophil counts of less than 1,500 cells/mm3. In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, it is recommended that frequent peripheral blood cell counts be performed on all patients receiving ABRAXANE. Note: An albumin form of paclitaxel may substantially affect a drug’s functional properties relative to those of drug in solution. DO NOT SUBSTITUTE FOR OR WITH OTHER PACLITAXEL FORMULATIONS. HOW MEDICINE IS ADMINISTERED? TOP Use this medicine exactly as directed on the label, unless instructed differently by your doctor * This medication is usually given by injection and administered by a healthcare professional. * Patient should read specific "MEDICATION GUIDE" provided with this medicine before starting treatment and each time their prescription is renewed. * To reconstitute, SWIRL, DO NOT SHAKE. WARNINGS/PRECAUTIONS: TOP * This medicine is CONTRAINDICATED for use during pregnancy. CALL YOUR DOCTOR IMMEDIATELY IF PREGNANT or intend to become pregnant. * Discontinue use and notify doctor at the first sign of a skin rash or other allergic reaction. * Men and women wishing to have children, should discontinue this medication and undergo a drug elimination procedure to minimize birth defects. Other Common Side Effects: TOP Abnormally low platelet count; Anemia; Liver functional problem; Numbness or tingling in hands and feet; Low blood pressure; Ulcer of mouth and other gi sites; Diarrhea; Vomiting; Nausea; Joint pain; Muscle pain; Muscle weakness; Baldness; Fluid retention; Difficulty breathing; Slowness of heartbeat; Unusual bleeding or bruising; Liver problems; Abnormal blood cell count. Other Common Side Effects: If symptoms are mild but do not go away or are bothersome, check with your doctor. IF ANY OF THE ABOVE SIDE EFFECTS IS SEVERE, CALL YOUR DOCTOR IMMEDIATELY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. This leaflet has been developed by CliniDATA Source, Inc. based primarily on labeling information provided by the manufacturer. The information does not cover all possible uses, actions, precautions, side effects, or interactions of this medicine. It is not intended as medical advice for individual patients. Copyright © CliniDATA Source, Inc. 03/14. All rights reserved